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A Video of a Beating Stem Cell Heart

decel-heart

Image credit: Photographs showing each step of the decellularization process.

In August this year, a team of scientists from University of Pittsburgh showed that they had a mouse heart taken out of its own cells and repopulated it with human stem cells, in the end, they made it possible for the mouse heart to beat again.

After twenty-day perfusion, the mouse’s heart tissue demonstrated the spontaneous contractions with beating rate of 40 to 50 beats every minute and was able to respond to different drugs.

Although it is regarded as an absolutely amazing feat, there is still a long to go before scientists could allow the heart contractions to be so strong to pump blood in an effective way, thus ensuring the rate at which the heart could speed up and slow down in a normal condition.

If you would like to know more about this case, you had better to read the paper recently published in Nature Communications.

Journal reference: Lu, Tung-Ying, et al. “Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells.” Nature communications 4 (2013).

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